Octet / Reactions
Acetoacetic Ester Synthesis
Included in Reactions.
Substitution
Source Details
Id
acetoacetic-ester-synthesis
Name
{
"en": "Acetoacetic Ester Synthesis",
"ar": "Acetoacetic إستر تحضير",
"cs": "Acetoacetic Ester Synteza",
"da": "Acetoacetic Ester Syntese",
"de": "Acetoacetic Ester Synthese",
"el": "Acetoacetic Εστέρας Σύνθεση",
"es-419": "Síntesis acétoacétique",
"es-ES": "Síntesis acétoacétique",
"es": "Síntesis acétoacétique",
"fi": "Acetoacetic Esteri Synteesi",
"fr": "Synthèse acétoacétique",
"he": "Acetoacetic אסטר סינתזה",
"hr": "Acetoacetic Ester Sinteza",
"hu": "Acetoacetic Észter Szbantézis",
"id": "Sintesis Ester Asetoasetat",
"it": "Sintesi acétoacétique",
"ja": "アセト酢酸エステル合成",
"ko": "아세토아세트산 에스터 합성",
"lv": "Acetoacetic Esteris Sinteze",
"nb": "Acetoacetic Ester Syntese",
"nl": "Acetoacetic Ester Synthese",
"pl": "Acetoacetic Ester Synteza",
"pt-BR": "Síntese acétoacétique",
"pt-PT": "Síntese acétoacétique",
"ro": "Sinteză acétoacétique",
"ru": "Acetoacetic Эфир Синтез",
"sk": "Acetoacetic Ester Synteza",
"sl": "Acetoacetic Ester Sinteza",
"sv": "Acetoacetic Ester Syntes",
"th": "การสังเคราะห์เอสเทอร์อะซีโตอะซิติก",
"tr": "Acetoacetic Ester Sentez",
"uk": "Acetoacetic Естер Синтез",
"vi": "Tổng hợp acetoacetic ester",
"zh-Hans": "乙酰乙酸酯合成",
"zh": "乙酰乙酸酯合成"
}Type
{
"en": "Substitution",
"ar": "استبدال",
"cs": "Substituce",
"da": "Substitution",
"de": "Substitution",
"el": "Υποκατάσταση",
"es-419": "Sustitución",
"es-ES": "Sustitución",
"es": "Sustitución",
"fi": "Substituutio",
"fr": "Substitution",
"he": "התמרה",
"hr": "Supstitucija",
"hu": "Szubsztitúció",
"id": "Substitusi",
"it": "Sostituzione",
"ja": "置換",
"ko": "치환",
"lv": "Aizvietošana",
"nb": "Substitusjon",
"nl": "Substitutie",
"pl": "Substytucja",
"pt-BR": "Substituição",
"pt-PT": "Substituição",
"ro": "Substituție",
"ru": "Замещение",
"sk": "Substitúcia",
"sl": "Substitucija",
"sv": "Substitution",
"th": "การแทนที่",
"tr": "Yer değiştirme",
"uk": "Заміщення",
"vi": "Thế",
"zh-Hans": "取代",
"zh": "取代"
}Starting Material
CCOC(=O)CC(=O)C
Product
CCC(=O)C
Reagents
NaOEt, R-X, then H₃O⁺/heat
Mechanism
[
{
"smiles": "CCOC(=O)CC(=O)C",
"description": {
"en": "Ethyl acetoacetate: acidic α-H (pKa ~11)",
"ar": "إيثيل acetoacetate: حمضي α-H (pKa ~11)",
"cs": "Ethyl acetoacetate: kysele α-H (pKa ~11)",
"da": "Ethylacetoacetat: acidic α-H (pKa ~11)",
"de": "Ethylacetoacetat: acidic α-H (pKa ~11)",
"el": "Ethyl acetoacetσεe: οξύic α-H (pKa ~11)",
"es-419": "Etil acetoacetate: acidic α-H (pKa ~11)",
"es-ES": "Etil acetoacetate: acidic α-H (pKa ~11)",
"es": "Etil acetoacetate: acidic α-H (pKa ~11)",
"fi": "Etyyliasetoasetaatti: acidic α-H (pKa ~11)",
"fr": "Éthyle acetoacetate: acidic α-H (pKa ~11)",
"he": "אתיל acetoacetate: חומצי α-H (pKa ~11)",
"hr": "Ethyl acetoacetate: kiseo α-H (pKa ~11)",
"hu": "Ethyl acetoacetnále: savic α-H (pKa ~11)",
"id": "Etil asetoasetat: α-H asam (pKa ~11)",
"it": "Etile acetoacetate: acidic α-H (pKa ~11)",
"ja": "アセト酢酸エチル: 酸性α-H（pKa ~11）",
"ko": "에틸 아세토아세테이트: 산성 α-H(pKa ~11)",
"lv": "Ethyl acetoacetate: skabs α-H (pKa ~11)",
"nb": "Etylacetoacetat: acidic α-H (pKa ~11)",
"nl": "Ethylacetoacetaat: acidic α-H (pKa ~11)",
"pl": "Ethyl acetoacetate: kwasowy α-H (pKa ~11)",
"pt-BR": "Etil acetoacetate: acidic α-H (pKa ~11)",
"pt-PT": "Etil acetoacetate: acidic α-H (pKa ~11)",
"ro": "Etil acetoacetate: acidic α-H (pKa ~11)",
"ru": "Ethyl acetoacetate: кислый α-H (pKa ~11)",
"sk": "Ethyl acetoacetate: kysly α-H (pKa ~11)",
"sl": "Ethyl acetoacetate: kisel α-H (pKa ~11)",
"sv": "Etylacetoacetat: acidic α-H (pKa ~11)",
"th": "เอทิลอะซีโตอะซิเตต: α-H เป็นกรด (pKa ~11)",
"tr": "Ethyl acetoacetdee: olarakitic α-H (pKa ~11)",
"uk": "Ethyl acetoacetate: кислий α-H (pKa ~11)",
"vi": "Ethyl acetoacetate: α-H có tính axit (pKa ~11)",
"zh-Hans": "乙酰乙酸乙酯：酸性 α-H（pKa ~11）",
"zh": "乙酰乙酸乙酯：酸性 α-H（pKa ~11）"
}
},
{
"smiles": "CCOC(=O)CC(=O)C",
"description": {
"en": "Enolate alkylation",
"ar": "Enolate ألكلة",
"cs": "Enolat alkylace",
"da": "Enolat alkylation",
"de": "Enolat alkylation",
"el": "Ενολικό ανιόν alkylσεiσε",
"es-419": "Alquilación de enolato",
"es-ES": "Alquilación de enolato",
"es": "Alquilación de enolato",
"fi": "Enolaatti alkylation",
"fr": "Alkylation de l’énolate",
"he": "Enolate אלקילציה",
"hr": "Enolat alkilacija",
"hu": "Enbancslát alkylnálion",
"id": "Alkilasi enolat",
"it": "Alchilazione dell’enolato",
"ja": "エノラートのアルキル化",
"ko": "에놀레이트 알킬화",
"lv": "Enolats alkilesana",
"nb": "Enolat alkylation",
"nl": "Enolaat alkylation",
"pl": "Enolan alkilacja",
"pt-BR": "Alquilação de enolato",
"pt-PT": "Alquilação de enolato",
"ro": "Alchilarea enolatului",
"ru": "Енолят алкилирование",
"sk": "Enolat alkylacia",
"sl": "Enolat alkilacija",
"sv": "Enolat alkylation",
"th": "การแอลคิเลตของอีโนเลต",
"tr": "Eyoklde alkyldeiüzerinde",
"uk": "Енолят алкілування",
"vi": "Alkyl hóa enolate",
"zh-Hans": "烯醇盐烷基化",
"zh": "烯醇盐烷基化"
}
},
{
"smiles": "CCC(=O)C",
"description": {
"en": "Hydrolysis and decarboxylation → substituted ketone",
"ar": "تحلل مائي و decarboxylation → مستبدل كيتون",
"cs": "Hydrolyza a decarboxylation → substituovany keton",
"da": "Hydrolyse og decarboxylation → substitueret keton",
"de": "Hydrolyse und decarboxylation → substituiert Keton",
"el": "Υδρόλυση και decarboxylσεiσε → υποκατεστημένο κετόνη",
"es-419": "Hidrólisis y decarboxylation → substituted cetona",
"es-ES": "Hidrólisis y decarboxylation → substituted cetona",
"es": "Hidrólisis y decarboxylation → substituted cetona",
"fi": "Hydrolyysi ja decarboxylation → substituoitu ketoni",
"fr": "Hydrolyse et decarboxylation → substitut...Tips
[
{
"en": "Makes substituted ketones (methyl ketones)",
"ar": "يصنع مستبدل كيتونات (ميثيل كيتونات)",
"cs": "Cini substituovany ketony (methyl ketony)",
"da": "Makes substitueret ketones (methyl ketones)",
"de": "Makes substituiert ketones (methyl ketones)",
"el": "Makes υποκατεστημένο κετόνες (methyl κετόνες)",
"es-419": "Makes substituted cetonas (metil cetonas)",
"es-ES": "Makes substituted cetonas (metil cetonas)",
"es": "Makes substituted cetonas (metil cetonas)",
"fi": "Makes substituoitu ketones (methyl ketones)",
"fr": "Makes substituted cétones (méthyle cétones)",
"he": "יוצר מותמר קטונים (מתיל קטונים)",
"hr": "Cini supstituiran ketoni (metil ketoni)",
"hu": "Makes szubsztituált ketonbancsk (methyl ketonbancsk)",
"id": "Membuat keton tersubstitusi (metil keton)",
"it": "Makes substituted chetoni (metile chetoni)",
"ja": "置換ケトン（メチルケトン）を作る",
"ko": "치환 케톤(메틸 케톤)을 만듦",
"lv": "Padara aizvietots ketoni (metil ketoni)",
"nb": "Makes substituert ketones (methyl ketones)",
"nl": "Makes gesubstitueerd ketones (methyl ketones)",
"pl": "Czyni podstawiony ketony (metyl ketony)",
"pt-BR": "Makes substituted cetonas (metil cetonas)",
"pt-PT": "Makes substituted cetonas (metil cetonas)",
"ro": "Makes substituted cetone (metil cetone)",
"ru": "Делает замещенный кетоны (метил кетоны)",
"sk": "Robi substituovany ketony (metyl ketony)",
"sl": "Naredi substituiran ketoni (metil ketoni)",
"sv": "Makes substituerad ketones (methyl ketones)",
"th": "สร้างคีโตนที่ถูกแทนที่ (เมทิลคีโตน)",
"tr": "Makes sübstitüe ketüzerindelar (methyl ketüzerindelar)",
"uk": "Робить заміщений кетони (метил кетони)",
"vi": "Tạo xeton đã thế (methyl xeton)",
"zh-Hans": "制备取代酮（甲基酮）",
"zh": "制备取代酮（甲基酮）"
},
{
"en": "Decarboxylation of β-keto acid",
"ar": "Decarboxylation من β-كيتو حمض",
"cs": "Decarboxylation z β-keto kyselina",
"da": "Decarboxylation of β-keto syre",
"de": "Decarboxylation of β-keto Säure",
"el": "Decarboxylσεiσε της β-keto οξύ",
"es-419": "Decarboxylation of β-keto ácido",
"es-ES": "Decarboxylation of β-keto ácido",
"es": "Decarboxylation of β-keto ácido",
"fi": "Decarboxylation of β-keto happo",
"fr": "Decarboxylation of β-keto acide",
"he": "Decarboxylation של β-קטו חומצה",
"hr": "Decarboxylation od β-keto kiselina",
"hu": "Decarboxylnálion of β-keto sav",
"id": "Dekarboksilasi asam β-keto",
"it": "Decarboxylation of β-keto acido",
"ja": "β-ケト酸の脱炭酸",
"ko": "β-케토산의 탈카복실화",
"lv": "Decarboxylation nav β-keto skabe",
"nb": "Decarboxylation of β-keto syre",
"nl": "Decarboxylation of β-keto zuur",
"pl": "Decarboxylation z β-keto kwas",
"pt-BR": "Decarboxylation of β-keto ácido",
"pt-PT": "Decarboxylation of β-keto ácido",
"ro": "Decarboxilarea β-cetoacidului",
"ru": "Decarboxylation из β-keto кислота",
"sk": "Decarboxylation z β-keto kyselina",
"sl": "Decarboxylation od β-keto kislina",
"sv": "Decarboxylation of β-keto syra",
"th": "ดีคาร์บอกซิเลชันของกรด β-คีโต",
"tr": "Decarboxyldeiüzerinde β-keto olarakit",
"uk": "Decarboxylation з β-keto кислота",
"vi": "Khử carboxyl của axit β-keto",
"zh-Hans": "β-酮酸脱羧",
"zh": "β-酮酸脱羧"
},
{
"en": "Can alkylate twice",
"ar": "يمكن alkylate twice",
"cs": "Může alkylovat dvakrát",
"da": "Kan alkyleres to gange",
"de": "Kann zweimal alkyliert werden",
"el": "Can alkylσεe twice",
"es-419": "Puede alquilar dos veces",
"es-ES": "Puede alquilar dos veces",
"es": "Puede alquilar dos veces",
"fi": "Voi alkyloitua kahdesti",
"fr": "Peut alkyler deux fois",
"he": "יכול alkylate twice",
"hr": "Može alkilirati dvaput",
"hu": "Can alkylnále twice",
"id": "Dapat dialkilasi dua kali",
"it": "Può alchilare due volte",
"ja": "2回アルキル化できる",
"ko": "두 번 알킬화 가능",
"lv": "Var alk...Related Reactions
malonic-ester-synthesis
Is Free
false