Octet / Reactions
Amide Formation from Acyl Chloride
Amide Formation from Acyl Chloride (Carbonyl). Starts from Acetyl chloride with CH₃NH₂, excess amine or with base. Mechanism in 2 steps.
Carbonyl
Reaction details
Name
Amide Formation from Acyl Chloride
Type
Carbonyl
Starting Material
CC(=O)Cl
Product
CC(=O)NC
Reagents
CH₃NH₂
excess amine or with base
Mechanism
- Smiles
CC(=O)Cl
- Description
Acetyl chloride
- Smiles
CC(=O)NC
- Description
N-methylacetamide (amine attacks, Cl⁻ leaves)
Tips
Use 2 eq amine (one acts as base) or add Et₃N
Most stable carboxylic acid derivative
Peptide bonds are amide bonds
Related Reactions
acyl-chloride-formation
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