Octet / Reactions
Mannich Reaction
Included in Reactions.
Addition
Source Details
Id
mannich-reaction
Name
{
"en": "Mannich Reaction",
"ar": "Mannich تفاعل",
"cs": "Mannich Reakce",
"da": "Mannich Reaktion",
"de": "Mannich Reaktion",
"el": "Αντίδραση Mannich",
"es-419": "Reacción de Mannich",
"es-ES": "Reacción de Mannich",
"es": "Reacción de Mannich",
"fi": "Mannich Reaktio",
"fr": "Réaction de Mannich",
"he": "Mannich תגובה",
"hr": "Mannich Reakcija",
"hu": "Mannich-reakció",
"id": "Reaksi Mannich",
"it": "Reazione di Mannich",
"ja": "Mannich反応",
"ko": "Mannich 반응",
"lv": "Mannich Reakcija",
"nb": "Mannich Reaksjon",
"nl": "Mannich Reactie",
"pl": "Mannich Reakcja",
"pt-BR": "Reação de Mannich",
"pt-PT": "Reação de Mannich",
"ro": "Reacție de Mannich",
"ru": "Mannich Реакция",
"sk": "Mannich Reakcia",
"sl": "Mannich Reakcija",
"sv": "Mannich Reaktion",
"th": "ปฏิกิริยา Mannich",
"tr": "Mannich reaksiyüzerindeu",
"uk": "Mannich Реакція",
"vi": "Phản ứng Mannich",
"zh-Hans": "Mannich 反应",
"zh": "Mannich 反应"
}Type
{
"en": "Addition",
"ar": "إضافة",
"cs": "Adice",
"da": "Addition",
"de": "Addition",
"el": "Προσθήκη",
"es-419": "Adición",
"es-ES": "Adición",
"es": "Adición",
"fi": "Additio",
"fr": "Addition",
"he": "סיפוח",
"hr": "Adicija",
"hu": "Addíció",
"id": "Adisi",
"it": "Addizione",
"ja": "付加",
"ko": "첨가",
"lv": "Pievienošana",
"nb": "Addisjon",
"nl": "Additie",
"pl": "Addycja",
"pt-BR": "Adição",
"pt-PT": "Adição",
"ro": "Adiție",
"ru": "Присоединение",
"sk": "Adícia",
"sl": "Adicija",
"sv": "Addition",
"th": "การเติม",
"tr": "Katılma",
"uk": "Приєднання",
"vi": "Cộng",
"zh-Hans": "加成",
"zh": "加成"
}Starting Material
CC(=O)C
Product
CC(=O)CCN(C)C
Reagents
HCHO, R₂NH (or NH₃), acid catalyst
Mechanism
[
{
"smiles": "CC(=O)C",
"description": {
"en": "Enolizable ketone",
"ar": "Enolizable كيتون",
"cs": "Enolizable keton",
"da": "Enolizable keton",
"de": "Enolizable Keton",
"el": "Eόχιlizable κετόνη",
"es-419": "Enolizable cetona",
"es-ES": "Enolizable cetona",
"es": "Enolizable cetona",
"fi": "Enolizable ketoni",
"fr": "Enolizable cétone",
"he": "Enolizable קטון",
"hr": "Enolizable keton",
"hu": "Enbancslizable keton",
"id": "Keton yang dapat dienolisasi",
"it": "Enolizable chetone",
"ja": "エノール化可能なケトン",
"ko": "엔올화 가능한 케톤",
"lv": "Enolizable ketons",
"nb": "Enolizable keton",
"nl": "Enolizable keton",
"pl": "Enolizable keton",
"pt-BR": "Enolizable cetona",
"pt-PT": "Enolizable cetona",
"ro": "Enolizable cetonă",
"ru": "Enolizable кетон",
"sk": "Enolizable keton",
"sl": "Enolizable keton",
"sv": "Enolizable keton",
"th": "คีโตนที่เกิดอีนอลได้",
"tr": "Eyoklizable ketüzerinde",
"uk": "Enolizable кетон",
"vi": "Xeton có thể enol hóa",
"zh-Hans": "可烯醇化酮",
"zh": "可烯醇化酮"
}
},
{
"smiles": "C=NCC",
"description": {
"en": "Iminium ion forms from formaldehyde + amine",
"ar": "Iminium أيون يتكوّن من فورمالدهيد + أمين",
"cs": "Iminium ion vznika z formaldehyde + amin",
"da": "Iminium ion danner fra formaldehyde + amin",
"de": "Iminium ion bildet aus formaldehyde + Amin",
"el": "Imσεium iσε σχηματίζεται από γιαmaldehyde + αμίνη",
"es-419": "Iminium ion se forma desde formaldehyde + amina",
"es-ES": "Iminium ion se forma desde formaldehyde + amina",
"es": "Iminium ion se forma desde formaldehyde + amina",
"fi": "Iminium ion muodostaa lähtien formaldehyde + amiini",
"fr": "Iminium ion se forme à partir de formaldehyde + amine",
"he": "Iminium יון נוצר מ פורמלדהיד + אמין",
"hr": "Iminium ion nastaje iz formaldehyde + amin",
"hu": "Imbanium ion képződik ebből számáramaldehyde + amban",
"id": "Ion iminium terbentuk dari formaldehida + amina",
"it": "Iminium ion si forma da formaldehyde + ammina",
"ja": "ホルムアルデヒド + アミンからイミニウムイオンが形成する",
"ko": "포름알데하이드 + 아민에서 이미늄 이온이 형성됨",
"lv": "Iminium jons veidojas nav formaldehyde + amins",
"nb": "Iminium ion danner fra formaldehyde + amin",
"nl": "Iminium ion vormt uit formaldehyde + amine",
"pl": "Iminium jon powstaje z formaldehyde + amina",
"pt-BR": "Iminium ion se forma de formaldehyde + amina",
"pt-PT": "Iminium ion se forma de formaldehyde + amina",
"ro": "Iminium ion se formează din formaldehyde + amină",
"ru": "Iminium ион образуется из formaldehyde + амин",
"sk": "Iminium ion vznika z formaldehyde + amin",
"sl": "Iminium ion nastane iz formaldehyde + amin",
"sv": "Iminium ion bildar från formaldehyde + amin",
"th": "ไอออนอิมิเนียมเกิดจากฟอร์มาลดีไฮด์ + เอมีน",
"tr": "Imiçindeium iüzerinde oluşur den içiçindemaldehyde + amiçinde",
"uk": "Iminium іон утворюється з formaldehyde + амін",
"vi": "Ion iminium hình thành từ formaldehyde + amin",
"zh-Hans": "甲醛 + 胺形成亚胺鎓离子",
"zh": "甲醛 + 胺形成亚胺鎓离子"
}
},
{
"smiles": "CC(=O)CCN(C)C",
"description": {
"en": "Enol attacks iminium → β-amino ketone (Mannich base)",
"ar": "Enol يهاجم إيمينيوم → β-أمينو كيتون (Mannich قاعدة)",
"cs": "Enol utoci iminium → β-amino keton (Mannich baze)",
"da": "Enol angriber iminium → β-amino keton (Mannich base)",
"de": "Enol greift an iminium → β-amino Keton (Mannich Base)",
"el": "Eόχιl επιτίθεται imσεium → β-amiόχι κετόνη (Mannich βάση)",
"es-419": "Enol ataca iminium → β-amino cetona (Mannich base)",
"es-ES": "Enol ataca iminium → β-amino cetona (Mannich base)",
"es": "Enol ataca iminium → β-amino cetona (Mannich base)",...Tips
[
{
"en": "Three-component reaction: C-H acid + aldehyde + amine",
"ar": "Three-component تفاعل: C-H حمض + ألدهيد + أمين",
"cs": "Three-component reakce: C-H kyselina + aldehyd + amin",
"da": "Three-component reaction: C-H syre + aldehyd + amin",
"de": "Three-component reaction: C-H Säure + Aldehyd + Amin",
"el": "Three-compέναnt αντίδραση: C-H οξύ + αλδεΰδη + αμίνη",
"es-419": "Tres-component reaction: C-H ácido + aldehído + amina",
"es-ES": "Tres-component reaction: C-H ácido + aldehído + amina",
"es": "Tres-component reaction: C-H ácido + aldehído + amina",
"fi": "Three-component reaction: C-H happo + aldehydi + amiini",
"fr": "Trois-component reaction: C-H acide + aldéhyde + amine",
"he": "Three-component תגובה: C-H חומצה + אלדהיד + אמין",
"hr": "Three-component reakcija: C-H kiselina + aldehid + amin",
"hu": "Three-compegynt reakció: C-H sav + aldehid + amban",
"id": "Reaksi tiga komponen: asam C-H + aldehida + amina",
"it": "Tre-component reaction: C-H acido + aldeide + ammina",
"ja": "三成分反応: C-H酸 + アルデヒド + アミン",
"ko": "3성분 반응: C-H 산 + 알데하이드 + 아민",
"lv": "Three-component reakcija: C-H skabe + aldehids + amins",
"nb": "Three-component reaction: C-H syre + aldehyd + amin",
"nl": "Three-component reaction: C-H zuur + aldehyde + amine",
"pl": "Three-component reakcja: C-H kwas + aldehyd + amina",
"pt-BR": "Três-component reaction: C-H ácido + aldeído + amina",
"pt-PT": "Três-component reaction: C-H ácido + aldeído + amina",
"ro": "Trei-component reaction: C-H acid + aldehidă + amină",
"ru": "Three-component реакция: C-H кислота + альдегид + амин",
"sk": "Three-component reakcia: C-H kyselina + aldehyd + amin",
"sl": "Three-component reakcija: C-H kislina + aldehid + amin",
"sv": "Three-component reaction: C-H syra + aldehyd + amin",
"th": "ปฏิกิริยา 3 องค์ประกอบ: กรด C-H + แอลดีไฮด์ + เอมีน",
"tr": "Üç bileşenli reaksiyüzerinde: C-H olarakit + aldehit + amiçinde",
"uk": "Three-component реакція: C-H кислота + альдегід + амін",
"vi": "Phản ứng ba thành phần: axit C-H + aldehit + amin",
"zh-Hans": "三组分反应：C-H 酸 + 醛 + 胺",
"zh": "三组分反应：C-H 酸 + 醛 + 胺"
},
{
"en": "Product is β-amino carbonyl (Mannich base)",
"ar": "الناتج هو β-أمينو كربونيل (Mannich قاعدة)",
"cs": "Produkt je β-amino karbonyl (Mannich baze)",
"da": "Produkt er β-amino carbonyl (Mannich base)",
"de": "Produkt ist β-amino Carbonyl (Mannich Base)",
"el": "Προϊόν is β-amiόχι καρβονύλιο (Mannich βάση)",
"es-419": "Producto es β-amino carbonoyl (Mannich base)",
"es-ES": "Producto es β-amino carbonoyl (Mannich base)",
"es": "Producto es β-amino carbonoyl (Mannich base)",
"fi": "Tuote on β-amino karbonyyli (Mannich emäs)",
"fr": "Produit est β-amino carboneyl (Mannich base)",
"he": "תוצר הוא β-אמינו קרבוניל (Mannich בסיס)",
"hr": "Produkt je β-amino karbonil (Mannich baza)",
"hu": "Termék is β-ambanbancs karbonil (Mannich bázis)",
"id": "Produk adalah karbonil β-amino (basa Mannich)",
"it": "Prodotto è β-amino carbonioyl (Mannich base)",
"ja": "生成物はβ-アミノカルボニル（Mannich塩基）",
"ko": "생성물은 β-아미노 카보닐(Mannich 염기)",
"lv": "Produkts ir β-amino karbonils (Mannich baze)",
"nb": "Produkt er β-amino karbonyl (Mannich base)",
"nl": "Product is β-aminocarbonyl (Mannich-base)",
"pl": "Produkt jest β-amino karbonyl (Mannich zasada)",
"pt-BR": "Produto é β-amino carbonoyl (Mannich base)",
"pt-PT": "Produto é β-amino carbonoyl (Mannich base)",
"ro": "Produs este β-amino carbonyl (Mannich bază)",
"ru": "Продукт является β-амино карбонил (Mannich основание)",
"sk": "Produkt je β-amino karbonyl (Mannich baza)",
"sl": "Produkt je β-amino karbonil (Mannich baza)",
"sv": "Produkt är β-amino karbonyl (Mannich bas)",
"th": "ผลิตภัณฑ์คือคาร์บอนิล β-อะมิโน (เบส Mannich)",
"tr": "Ürün β-amiyok karbüzerindeil (Mannich baz)",
"uk": "Пр...Related Reactions
aldol-addition
Is Free
false