Octet / Reactions
Michael Addition
Included in Reactions.
Carbonyl
Source Details
Id
michael-addition
Name
{
"en": "Michael Addition",
"ar": "Michael إضافة",
"cs": "Michael Adice",
"da": "Michaeladdition",
"de": "Michael-Addition",
"el": "Michael Προσθήκη",
"es-419": "Adición de Michael",
"es-ES": "Adición de Michael",
"es": "Adición de Michael",
"fi": "Michael Additio",
"fr": "Addition de Michael",
"he": "Michael סיפוח",
"hr": "Michael Adicija",
"hu": "Michael Addíció",
"id": "Adisi Michael",
"it": "Addizione di Michael",
"ja": "Michael付加",
"ko": "Michael 첨가",
"lv": "Michael Pievienosana",
"nb": "Michael Addisjon",
"nl": "Michael Additie",
"pl": "Michael Addycja",
"pt-BR": "Adição de Michael",
"pt-PT": "Adição de Michael",
"ro": "Adiție de Michael",
"ru": "Michael Присоединение",
"sk": "Michael Adicia",
"sl": "Michael Adicija",
"sv": "Michaeladdition",
"th": "การเติมแบบ Michael",
"tr": "Michael Kdeılma",
"uk": "Michael Приєднання",
"vi": "Cộng Michael",
"zh-Hans": "Michael 加成",
"zh": "Michael 加成"
}Type
{
"en": "Carbonyl",
"ar": "كربونيل",
"cs": "Karbonylová",
"da": "Carbonyl",
"de": "Carbonyl",
"el": "Καρβονύλιο",
"es-419": "Carbonilo",
"es-ES": "Carbonilo",
"es": "Carbonilo",
"fi": "Karbonyyli",
"fr": "Carbonyle",
"he": "קרבוניל",
"hr": "Karbonilna",
"hu": "Karbonil",
"id": "Karbonil",
"it": "Carbonile",
"ja": "カルボニル",
"ko": "카르보닐",
"lv": "Karbonilgrupa",
"nb": "Karbonyl",
"nl": "Carbonyl",
"pl": "Karbonylowa",
"pt-BR": "Carbonila",
"pt-PT": "Carbonila",
"ro": "Carbonil",
"ru": "Карбонильные",
"sk": "Karbonylová",
"sl": "Karbonilna",
"sv": "Karbonyl",
"th": "คาร์บอนิล",
"tr": "Karbonil",
"uk": "Карбонільні",
"vi": "Cacbonyl",
"zh-Hans": "羰基",
"zh": "羰基"
}Subtype
{
"en": "Conjugate Addition",
"ar": "إضافة مترافقة",
"cs": "Konjugovaná adice",
"da": "Konjugeret addition",
"de": "Konjugierte Addition",
"el": "Συζυγιακή προσθήκη",
"es-419": "Adición conjugada",
"es-ES": "Adición conjugada",
"es": "Adición conjugada",
"fi": "Konjugoitu additio",
"fr": "Addition conjuguée",
"he": "סיפוח מצומד",
"hr": "Konjugirana adicija",
"hu": "Konjugált addíció",
"id": "Adisi konjugat",
"it": "Addizione coniugata",
"ja": "共役付加",
"ko": "공액 첨가",
"lv": "Konjugētā adīcija",
"nb": "Konjugert addisjon",
"nl": "Geconjugeerde additie",
"pl": "Addycja sprzężona",
"pt-BR": "Adição conjugada",
"pt-PT": "Adição conjugada",
"ro": "Adiție conjugată",
"ru": "Сопряжённое присоединение",
"sk": "Konjugovaná adícia",
"sl": "Konjugirana adicija",
"sv": "Konjugerad addition",
"th": "การเติมแบบคอนจูเกต",
"tr": "Konjuge katılma",
"uk": "Спряжене приєднання",
"vi": "Cộng liên hợp",
"zh-Hans": "共轭加成",
"zh": "共轭加成"
}Starting Material
CC(=O)C=C
Product
CC(=O)CCC#N
Reagents
Nucleophile (enolate, CN⁻, amine, thiol)
Mechanism
[
{
"smiles": "CC(=O)C=C",
"description": {
"en": "α,β-unsaturated ketone (MVK)",
"ar": "α,β-غير مشبع كيتون (MVK)",
"cs": "α,β-nenasyceny keton (MVK)",
"da": "α,β-unsaturated keton (MVK)",
"de": "α,β-unsaturated Keton (MVK)",
"el": "α,β-unsσεurσεed κετόνη (MVK)",
"es-419": "α,β-unsaturated cetona (MVK)",
"es-ES": "α,β-unsaturated cetona (MVK)",
"es": "α,β-unsaturated cetona (MVK)",
"fi": "α,β-unsaturated ketoni (MVK)",
"fr": "α,β-unsaturated cétone (MVK)",
"he": "α,β-לא רווי קטון (MVK)",
"hr": "α,β-nezasiceni keton (MVK)",
"hu": "α,β-unsnálurnáled keton (MVK)",
"id": "Keton α,β-tak jenuh (MVK)",
"it": "α,β-unsaturated chetone (MVK)",
"ja": "α,β-不飽和ケトン（MVK）",
"ko": "α,β-불포화 케톤(MVK)",
"lv": "α,β-nepiesatinats ketons (MVK)",
"nb": "α,β-unsaturated keton (MVK)",
"nl": "α,β-unsaturated keton (MVK)",
"pl": "α,β-nienasycony keton (MVK)",
"pt-BR": "α,β-unsaturated cetona (MVK)",
"pt-PT": "α,β-unsaturated cetona (MVK)",
"ro": "α,β-unsaturated cetonă (MVK)",
"ru": "α,β-ненасыщенный кетон (MVK)",
"sk": "α,β-nenasyteny keton (MVK)",
"sl": "α,β-nenasicen keton (MVK)",
"sv": "α,β-unsaturated keton (MVK)",
"th": "คีโตน α,β-ไม่อิ่มตัว (MVK)",
"tr": "α,β-unsdeurdeed ketüzerinde (MVK)",
"uk": "α,β-ненасичений кетон (MVK)",
"vi": "Xeton α,β-không no (MVK)",
"zh-Hans": "α,β-不饱和酮（MVK）",
"zh": "α,β-不饱和酮（MVK）"
}
},
{
"smiles": "CC(=O)CCC#N",
"description": {
"en": "Nucleophile added to β-carbon (1,4-addition)",
"ar": "Nucleophile مضاف إلى β-كربون (1,4-إضافة)",
"cs": "Nukleofil added na β-uhlik (1,4-adice)",
"da": "Nukleofil added til β-kulstof (1,4-addition)",
"de": "Nukleophil added zu β-Kohlenstoff (1,4-addition)",
"el": "Πυρηνόφιλο added σε β-άνθρακας (1,4-προσθήκη)",
"es-419": "Nucleófilo added a β-carbon (1,4-adición)",
"es-ES": "Nucleófilo added a β-carbon (1,4-adición)",
"es": "Nucleófilo added a β-carbon (1,4-adición)",
"fi": "Nukleofiili added kohti β-hiili (1,4-addition)",
"fr": "Nucléophile added en β-carbon (1,4-addition)",
"he": "Nucleophile נוסף ל β-פחמן (1,4-סיפוח)",
"hr": "Nukleofil added u β-ugljik (1,4-adicija)",
"hu": "Nukleofil added to β-szén (1,4-addíció)",
"id": "Nukleofil ditambahkan ke β-karbon (adisi 1,4)",
"it": "Nucleofilo added a β-carbon (1,4-addizione)",
"ja": "求核剤がβ-炭素に付加する（1,4-付加）",
"ko": "친핵체가 β-탄소에 첨가됨(1,4-첨가)",
"lv": "Nukleofils added uz β-ogleklis (1,4-pievienosana)",
"nb": "Nukleofil added til β-karbon (1,4-addition)",
"nl": "Nucleofiel added tot β-koolstof (1,4-addition)",
"pl": "Nukleofil added do β-wegiel (1,4-addycja)",
"pt-BR": "Nucleófilo added a β-carbon (1,4-adição)",
"pt-PT": "Nucleófilo added a β-carbon (1,4-adição)",
"ro": "Nucleofil added la β-carbon (1,4-adiție)",
"ru": "Нуклеофил added в β-углерод (1,4-присоединение)",
"sk": "Nukleofil added na β-uhlik (1,4-adicia)",
"sl": "Nukleofil added v β-ogljik (1,4-adicija)",
"sv": "Nukleofil added till β-kol (1,4-addition)",
"th": "นิวคลีโอไฟล์เติมเข้าที่คาร์บอนตำแหน่ง β (การเติมแบบ 1,4)",
"tr": "Nükleofil β-karbüzerindea eklenir (1,4-kdeılma)",
"uk": "Нуклеофіл added до β-вуглець (1,4-приєднання)",
"vi": "Ái nhân cộng vào β-carbon (cộng 1,4)",
"zh-Hans": "亲核试剂加到 β-碳（1,4-加成）",
"zh": "亲核试剂加到 β-碳（1,4-加成）"
}
}
]Tips
[
{
"en": "Conjugate (1,4) addition to α,β-unsaturated carbonyl",
"ar": "مقترن (1,4) إضافة إلى α,β-غير مشبع كربونيل",
"cs": "Conjugate (1,4) adice na α,β-nenasyceny karbonyl",
"da": "Conjugate (1,4) addition til α,β-unsaturated carbonyl",
"de": "Conjugate (1,4) addition zu α,β-unsaturated Carbonyl",
"el": "Cσεjugσεe (1,4) προσθήκη σε α,β-unsσεurσεed καρβονύλιο",
"es-419": "Conjugate (1,4) adición a α,β-unsaturated carbonoyl",
"es-ES": "Conjugate (1,4) adición a α,β-unsaturated carbonoyl",
"es": "Conjugate (1,4) adición a α,β-unsaturated carbonoyl",
"fi": "Conjugate (1,4) addition kohti α,β-unsaturated karbonyyli",
"fr": "Conjugate (1,4) addition en α,β-unsaturated carboneyl",
"he": "מצומד (1,4) סיפוח ל α,β-לא רווי קרבוניל",
"hr": "Conjugate (1,4) adicija u α,β-nezasiceni karbonil",
"hu": "Conjugnále (1,4) addíció to α,β-unsnálurnáled karbonil",
"id": "Adisi konjugat (1,4) ke karbonil α,β-tak jenuh",
"it": "Conjugate (1,4) addizione a α,β-unsaturated carbonioyl",
"ja": "α,β-不飽和カルボニルへの共役（1,4）付加",
"ko": "α,β-불포화 카보닐에 대한 공액(1,4) 첨가",
"lv": "Conjugate (1,4) pievienosana uz α,β-nepiesatinats karbonils",
"nb": "Conjugate (1,4) addition til α,β-unsaturated karbonyl",
"nl": "Conjugate (1,4) addition tot α,β-unsaturated carbonyl",
"pl": "Conjugate (1,4) addycja do α,β-nienasycony karbonyl",
"pt-BR": "Conjugate (1,4) adição a α,β-unsaturated carbonoyl",
"pt-PT": "Conjugate (1,4) adição a α,β-unsaturated carbonoyl",
"ro": "Conjugate (1,4) adiție la α,β-unsaturated carbonyl",
"ru": "Conjugate (1,4) присоединение в α,β-ненасыщенный карбонил",
"sk": "Conjugate (1,4) adicia na α,β-nenasyteny karbonyl",
"sl": "Conjugate (1,4) adicija v α,β-nenasicen karbonil",
"sv": "Conjugate (1,4) addition till α,β-unsaturated karbonyl",
"th": "การเติมแบบคอนจูเกต (1,4) เข้าคาร์บอนิล α,β-ไม่อิ่มตัว",
"tr": "Küzerindejuge (1,4) kdeılma α,β-unsdeurdeed karbüzerindeil",
"uk": "Conjugate (1,4) приєднання до α,β-ненасичений карбоніл",
"vi": "Cộng liên hợp (1,4) vào cacbonyl α,β-không no",
"zh-Hans": "对 α,β-不饱和羰基的共轭（1,4）加成",
"zh": "对 α,β-不饱和羰基的共轭（1,4）加成"
},
{
"en": "Soft nucleophiles prefer conjugate addition",
"ar": "Soft نيوكليوفيلات prefer مقترن إضافة",
"cs": "Soft nucleophiles prefer conjugate adice",
"da": "Bløde nukleofiler foretrækker konjugeret addition",
"de": "Weiche Nukleophile bevorzugen konjugierte Addition",
"el": "Soft πυρηνόφιλοs προτιμούν cσεjugσεe προσθήκη",
"es-419": "Soft nucleophiles prefer conjugate adición",
"es-ES": "Soft nucleophiles prefer conjugate adición",
"es": "Soft nucleophiles prefer conjugate adición",
"fi": "Pehmeät nukleofiilit suosivat konjugaattiadditiota",
"fr": "Les nucléophiles mous préfèrent l’addition conjuguée",
"he": "Soft נוקלאופילים prefer מצומד סיפוח",
"hr": "Soft nucleophiles prefer conjugate adicija",
"hu": "Soft nukleofils előnyben részesít conjugnále addíció",
"id": "Nukleofil lunak lebih menyukai adisi konjugat",
"it": "Soft nucleophiles prefer conjugate addizione",
"ja": "柔らかい求核剤は共役付加を好む",
"ko": "부드러운 친핵체는 공액 첨가를 선호함",
"lv": "Soft nucleophiles prefer conjugate pievienosana",
"nb": "Myke nukleofiler foretrekker konjugert addisjon",
"nl": "Zachte nucleofielen geven de voorkeur aan conjugaatadditie",
"pl": "Soft nucleophiles prefer conjugate addycja",
"pt-BR": "Soft nucleophiles prefer conjugate adição",
"pt-PT": "Soft nucleophiles prefer conjugate adição",
"ro": "Soft nucleophiles prefer conjugate adiție",
"ru": "Soft nucleophiles prefer conjugate присоединение",
"sk": "Soft nucleophiles prefer conjugate adicia",
"sl": "Soft nucleophiles prefer conjugate adicija",
"sv": "Mjuka nukleofiler föredrar konjugerad addition",
"th": "นิวคลีโอไฟล์ชนิดอ่อนชอบการเติมแบบคอนจูเกต",
"tr": "Soft nükleofils tercih eder cüzerindejugdee kdeılma",
"uk": "Soft nuc...Related Reactions
aldol-addition
Is Free
false