Octet / Reactions

Mitsunobu Reaction

Included in Reactions.

Substitution

Source Details

Id

mitsunobu-reaction

Name
{
  "en": "Mitsunobu Reaction",
  "ar": "Mitsunobu تفاعل",
  "cs": "Mitsunobu Reakce",
  "da": "Mitsunobu Reaktion",
  "de": "Mitsunobu Reaktion",
  "el": "Αντίδραση Mitsuόχιbu",
  "es-419": "Reacción de Mitsunobu",
  "es-ES": "Reacción de Mitsunobu",
  "es": "Reacción de Mitsunobu",
  "fi": "Mitsunobu Reaktio",
  "fr": "Réaction de Mitsunobu",
  "he": "Mitsunobu תגובה",
  "hr": "Mitsunobu Reakcija",
  "hu": "Mitsunbancsbu-reakció",
  "id": "Reaksi Mitsunobu",
  "it": "Reazione di Mitsunobu",
  "ja": "Mitsunobu反応",
  "ko": "Mitsunobu 반응",
  "lv": "Mitsunobu Reakcija",
  "nb": "Mitsunobu Reaksjon",
  "nl": "Mitsunobu Reactie",
  "pl": "Mitsunobu Reakcja",
  "pt-BR": "Reação de Mitsunobu",
  "pt-PT": "Reação de Mitsunobu",
  "ro": "Reacție de Mitsunobu",
  "ru": "Mitsunobu Реакция",
  "sk": "Mitsunobu Reakcia",
  "sl": "Mitsunobu Reakcija",
  "sv": "Mitsunobu Reaktion",
  "th": "ปฏิกิริยา Mitsunobu",
  "tr": "Mitsuyokbu reaksiyüzerindeu",
  "uk": "Mitsunobu Реакція",
  "vi": "Phản ứng Mitsunobu",
  "zh-Hans": "Mitsunobu 反应",
  "zh": "Mitsunobu 反应"
}
Type
{
  "en": "Substitution",
  "ar": "استبدال",
  "cs": "Substituce",
  "da": "Substitution",
  "de": "Substitution",
  "el": "Υποκατάσταση",
  "es-419": "Sustitución",
  "es-ES": "Sustitución",
  "es": "Sustitución",
  "fi": "Substituutio",
  "fr": "Substitution",
  "he": "התמרה",
  "hr": "Supstitucija",
  "hu": "Szubsztitúció",
  "id": "Substitusi",
  "it": "Sostituzione",
  "ja": "置換",
  "ko": "치환",
  "lv": "Aizvietošana",
  "nb": "Substitusjon",
  "nl": "Substitutie",
  "pl": "Substytucja",
  "pt-BR": "Substituição",
  "pt-PT": "Substituição",
  "ro": "Substituție",
  "ru": "Замещение",
  "sk": "Substitúcia",
  "sl": "Substitucija",
  "sv": "Substitution",
  "th": "การแทนที่",
  "tr": "Yer değiştirme",
  "uk": "Заміщення",
  "vi": "Thế",
  "zh-Hans": "取代",
  "zh": "取代"
}
Starting Material

CC(C)O

Product

CC(C)N3

Reagents

DEAD or DIAD, PPh₃, Nucleophile (pKa < 15)

Mechanism
[
  {
    "smiles": "CC(C)O",
    "description": {
      "en": "Secondary alcohol",
      "ar": "ثانوي كحول",
      "cs": "Sekundarni alkohol",
      "da": "Sekundær alkohol",
      "de": "Sekundär Alkohol",
      "el": "Δευτεροταγής αλκοόλη",
      "es-419": "Secundario alcohol",
      "es-ES": "Secundario alcohol",
      "es": "Secundario alcohol",
      "fi": "Sekundäärinen alkoholi",
      "fr": "Secondaire alcool",
      "he": "שניוני אלכוהול",
      "hr": "Sekundarni alkohol",
      "hu": "Szekunder alkohol",
      "id": "Alkohol sekunder",
      "it": "Secondario alcol",
      "ja": "第二級アルコール",
      "ko": "2차 알코올",
      "lv": "Sekundarais spirts",
      "nb": "Sekundær alkohol",
      "nl": "Secundair alcohol",
      "pl": "Drugorzędowy alkohol",
      "pt-BR": "Secundário álcool",
      "pt-PT": "Secundário álcool",
      "ro": "Secundar alcool",
      "ru": "Вторичный спирт",
      "sk": "Sekundarny alkohol",
      "sl": "Sekundarni alkohol",
      "sv": "Sekundär alkohol",
      "th": "แอลกอฮอล์ทุติยภูมิ",
      "tr": "İkiçindecil alkol",
      "uk": "Вторинний спирт",
      "vi": "Ancol bậc hai",
      "zh-Hans": "仲醇",
      "zh": "仲醇"
    }
  },
  {
    "smiles": "CC(C)O",
    "description": {
      "en": "PPh₃ + DEAD activate alcohol",
      "ar": "PPh₃ + DEAD activate كحول",
      "cs": "PPh₃ + DEAD activate alkohol",
      "da": "PPh₃ + DEAD activate alkohol",
      "de": "PPh₃ + DEAD activate Alkohol",
      "el": "PPh₃ + DEAD activσεe αλκοόλη",
      "es-419": "PPh₃ + DEAD activan el alcohol",
      "es-ES": "PPh₃ + DEAD activan el alcohol",
      "es": "PPh₃ + DEAD activan el alcohol",
      "fi": "PPh₃ + DEAD activate alkoholi",
      "fr": "PPh₃ + DEAD activate alcool",
      "he": "PPh₃ + DEAD activate אלכוהול",
      "hr": "PPh₃ + DEAD activate alkohol",
      "hu": "PPh₃ + DEAD activnále alkohol",
      "id": "PPh₃ + DEAD mengaktifkan alkohol",
      "it": "PPh₃ + DEAD activate alcol",
      "ja": "PPh₃ + DEADがアルコールを活性化する",
      "ko": "PPh₃ + DEAD가 알코올을 활성화함",
      "lv": "PPh₃ + DEAD activate spirts",
      "nb": "PPh₃ + DEAD activate alkohol",
      "nl": "PPh₃ + DEAD activeert alcohol",
      "pl": "PPh₃ + DEAD activate alkohol",
      "pt-BR": "PPh₃ + DEAD activate álcool",
      "pt-PT": "PPh₃ + DEAD activate álcool",
      "ro": "PPh₃ + DEAD activate alcool",
      "ru": "PPh₃ + DEAD activate спирт",
      "sk": "PPh₃ + DEAD activate alkohol",
      "sl": "PPh₃ + DEAD activate alkohol",
      "sv": "PPh₃ + DEAD activate alkohol",
      "th": "PPh₃ + DEAD ทำให้แอลกอฮอล์ถูกกระตุ้น",
      "tr": "PPh₃ + DEAD activdee alkol",
      "uk": "PPh₃ + DEAD activate спирт",
      "vi": "PPh₃ + DEAD hoạt hóa ancol",
      "zh-Hans": "PPh₃ + DEAD 活化醇",
      "zh": "PPh₃ + DEAD 活化醇"
    }
  },
  {
    "smiles": "CC(C)N3",
    "description": {
      "en": "Nucleophile displaces with INVERSION",
      "ar": "Nucleophile يزيح مع INVERSION",
      "cs": "Nukleofil displaces s INVERSION",
      "da": "Nukleofil displaces med INVERSION",
      "de": "Nukleophil displaces mit INVERSION",
      "el": "Πυρηνόφιλο displaces με INVERSION",
      "es-419": "Nucleófilo displaces con inversión",
      "es-ES": "Nucleófilo displaces con inversión",
      "es": "Nucleófilo displaces con inversión",
      "fi": "Nukleofiili displaces kanssa INVERSION",
      "fr": "Nucléophile displaces avec inversion",
      "he": "Nucleophile דוחק עם INVERSION",
      "hr": "Nukleofil displaces s INVERSION",
      "hu": "Nukleofil displaces vele INVERSION",
      "id": "Nukleofil menggantikan dengan INVERSI",
      "it": "Nucleofilo displaces con inversione",
      "ja": "求核剤が反転を伴って置換する",
      "ko": "친핵체가 반전을 동반해 치환함",
      "lv": "Nukleofils displaces ar INVERSION",
      "nb": "Nukleofil displaces med INVERSION",
      "nl": "Nucleofiel displaces met INVERSION",
      "pl": "Nukleofil displaces z INVERSION",
      "pt-BR": "Nucleófilo displaces com inversão",
      "pt-PT": "Nucleófilo displaces com inversão",
      "ro": "Nucleofil dis...
Stereochemistry
{
  "en": "Inversion of configuration (like SN2)",
  "ar": "انقلاب من تشكيل (like SN2)",
  "cs": "Inverze z konfigurace (like SN2)",
  "da": "Inversion of konfiguration (like SN2)",
  "de": "Inversion of Konfiguration (like SN2)",
  "el": "Αναστροφή της διαμόρφωση (like SN2)",
  "es-419": "Inversion of configuración (like SN2)",
  "es-ES": "Inversion of configuración (like SN2)",
  "es": "Inversion of configuración (like SN2)",
  "fi": "Inversion of konfiguraatio (like SN2)",
  "fr": "Inversion de configuration (comme SN2)",
  "he": "היפוך של קונפיגורציה (like SN2)",
  "hr": "Inverzija od konfiguracija (like SN2)",
  "hu": "Banverzió of konfiguráció (like SN2)",
  "id": "Inversi konfigurasi (seperti SN2)",
  "it": "Inversion of configurazione (like SN2)",
  "ja": "配置の反転(SN2のように)",
  "ko": "배치 반전(SN2와 유사)",
  "lv": "Inversija nav konfiguracija (like SN2)",
  "nb": "Inversion of konfigurasjon (like SN2)",
  "nl": "Inversion of configuratie (like SN2)",
  "pl": "Inwersja z konfiguracja (like SN2)",
  "pt-BR": "Inversion of configuração (like SN2)",
  "pt-PT": "Inversion of configuração (like SN2)",
  "ro": "Inversion of configurație (like SN2)",
  "ru": "Инверсия из конфигурация (like SN2)",
  "sk": "Inverzia z konfiguracia (like SN2)",
  "sl": "Inverzija od konfiguracija (like SN2)",
  "sv": "Inversion of konfiguration (like SN2)",
  "th": "การกลับด้านของคอนฟิกูเรชัน (เหมือน SN2)",
  "tr": "İnversiyüzerinde küzerindefigürolarakyüzerinde (like SN2)",
  "uk": "Інверсія з конфігурація (like SN2)",
  "vi": "Nghịch đảo cấu hình (giống SN2)",
  "zh-Hans": "构型反转(类似 SN2)",
  "zh": "构型反转(类似 SN2)"
}
Tips
[
  {
    "en": "Converts alcohol to other groups with INVERSION",
    "ar": "يحوّل كحول إلى أخرى مجموعات مع INVERSION",
    "cs": "Prevadi alkohol na jiny skupiny s INVERSION",
    "da": "Omdanner alkohol til other groups med INVERSION",
    "de": "Wandelt Alkohol zu other groups mit INVERSION",
    "el": "Cσεverts αλκοόλη σε other ομάδαs με INVERSION",
    "es-419": "Convierte alcohol a other groups con inversión",
    "es-ES": "Convierte alcohol a other groups con inversión",
    "es": "Convierte alcohol a other groups con inversión",
    "fi": "Muuntaa alkoholi kohti other groups kanssa INVERSION",
    "fr": "Convertit alcool en other groups avec inversion",
    "he": "ממיר אלכוהול ל אחר קבוצות עם INVERSION",
    "hr": "Pretvara alkohol u drugi skupine s INVERSION",
    "hu": "Converts alkohol to other csopvagyts vele INVERSION",
    "id": "Mengubah alkohol menjadi gugus lain dengan INVERSI",
    "it": "Converte alcol a other groups con inversione",
    "ja": "アルコールを他の官能基へ反転を伴って変換する",
    "ko": "알코올을 반전과 함께 다른 작용기로 바꿈",
    "lv": "Parvers spirts uz citi grupas ar INVERSION",
    "nb": "Omdanner alkohol til other groups med INVERSION",
    "nl": "Zet alcohol tot other groups met INVERSION",
    "pl": "Przeksztalca alkohol do inne grupy z INVERSION",
    "pt-BR": "Converte álcool a other groups com inversão",
    "pt-PT": "Converte álcool a other groups com inversão",
    "ro": "Convertește alcool la other groups cu inversie",
    "ru": "Превращает спирт в другой группы с INVERSION",
    "sk": "Premiena alkohol na iny skupiny s INVERSION",
    "sl": "Pretvori alkohol v drugi skupine z INVERSION",
    "sv": "Omvandlar alkohol till other groups med INVERSION",
    "th": "เปลี่ยนแอลกอฮอล์เป็นหมู่อื่นพร้อมการกลับด้าน",
    "tr": "Cüzerindeverts alkol to other grups ile INVERSION",
    "uk": "Перетворює спирт до інший групи з INVERSION",
    "vi": "Chuyển ancol thành nhóm khác kèm NGHỊCH ĐẢO",
    "zh-Hans": "将醇转化为其他基团并发生反转",
    "zh": "将醇转化为其他基团并发生反转"
  },
  {
    "en": "Nucleophiles: azides, phthalimide, carboxylic acids, phenols",
    "ar": "Nucleophiles: azides, phthalimide, أحماض كربوكسيلية, phenols",
    "cs": "Nucleophiles: azides, phthalimide, karboxylovy kyseliny, phenols",
    "da": "Nukleofiler: azider, phthalimid, carboxylsyrer, phenoler",
    "de": "Nukleophile: Azide, Phthalimid, Carbonsäuren, Phenole",
    "el": "Nucleophiles: azides, phthalimide, carboxylic οξύs, pheόχιls",
    "es-419": "Nucleófilos: azidas, ftalimida, ácidos carboxílicos, fenoles",
    "es-ES": "Nucleófilos: azidas, ftalimida, ácidos carboxílicos, fenoles",
    "es": "Nucleófilos: azidas, ftalimida, ácidos carboxílicos, fenoles",
    "fi": "Nukleofiilit: atsidit, ftalimidi, karboksyylihapot, fenolit",
    "fr": "Nucléophiles: azotures, phtalimide, acides carboxyliques, phénols",
    "he": "Nucleophiles: azides, phthalimide, חומצות קרבוקסיליות, phenols",
    "hr": "Nucleophiles: azides, phthalimide, karboksilni kiseline, phenols",
    "hu": "Nucleophiles: azides, phthalimide, carboxylic savs, phenbancsls",
    "id": "Nukleofil: azida, ftalimida, asam karboksilat, fenol",
    "it": "Nucleofili: azidi, ftalimmide, acidi carbossilici, fenoli",
    "ja": "求核剤: アジド、フタルイミド、カルボン酸、フェノール",
    "ko": "친핵체: 아자이드, 프탈이미드, 카복실산, 페놀",
    "lv": "Nucleophiles: azides, phthalimide, karbonskabes skabes, phenols",
    "nb": "Nukleofiler: azider, ftalimid, karboksylsyrer, fenoler",
    "nl": "Nucleofielen: aziden, ftalimide, carbonzuren, fenolen",
    "pl": "Nucleophiles: azides, phthalimide, karboksylowy kwasy, phenols",
    "pt-BR": "Nucleófilos: azidas, ftalimida, ácidos carboxílicos, fenóis",
    "pt-PT": "Nucleófilos: azidas, ftalimida, ácidos carboxílicos, fenóis",
    "ro": "Nucleofili: azide, ftalimidă, acizi carboxilici, fenoli",
    "ru": "Nucleophiles: azides, phthalimide, карбоновый кислоты, phenols",
    "sk": "Nucleophiles: azides, phthalimide, karboxylovy kyseliny, phenols",
    "sl": "Nucleophiles: azides, phthalimide, karboksilni kisline, phenols",...
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Is Free

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