Octet / Reactions
Williamson Ether Synthesis
Included in Reactions.
Substitution
Source Details
Id
williamson-ether
Name
{
"en": "Williamson Ether Synthesis",
"ar": "Williamson Ether تحضير",
"cs": "Williamson Ether Synteza",
"da": "Williamson Ether Syntese",
"de": "Williamson Ether Synthese",
"el": "Williamsσε Αιθέρας Σύνθεση",
"es-419": "Síntesis de éther de Williamson",
"es-ES": "Síntesis de éther de Williamson",
"es": "Síntesis de éther de Williamson",
"fi": "Williamson Eetteri Synteesi",
"fr": "Synthèse d'éther de Williamson",
"he": "Williamson Ether סינתזה",
"hr": "Williamson Eter Sinteza",
"hu": "Williamson Éter Szbantézis",
"id": "Sintesis Eter Williamson",
"it": "Sintesi di éther di Williamson",
"ja": "Williamsonエーテル合成",
"ko": "Williamson 에터 합성",
"lv": "Williamson Eteris Sinteze",
"nb": "Williamson Eter Syntese",
"nl": "Williamson Ether Synthese",
"pl": "Williamson Eter Synteza",
"pt-BR": "Síntese de éther de Williamson",
"pt-PT": "Síntese de éther de Williamson",
"ro": "Sinteză de éther de Williamson",
"ru": "Williamson Эфир Синтез",
"sk": "Williamson Eter Synteza",
"sl": "Williamson Eter Sinteza",
"sv": "Williamson Eter Syntes",
"th": "การสังเคราะห์อีเทอร์แบบ Williamson",
"tr": "Williamsüzerinde Eter Sentez",
"uk": "Williamson Етер Синтез",
"vi": "Tổng hợp ete Williamson",
"zh-Hans": "Williamson 醚合成",
"zh": "Williamson 醚合成"
}Type
{
"en": "Substitution",
"ar": "استبدال",
"cs": "Substituce",
"da": "Substitution",
"de": "Substitution",
"el": "Υποκατάσταση",
"es-419": "Sustitución",
"es-ES": "Sustitución",
"es": "Sustitución",
"fi": "Substituutio",
"fr": "Substitution",
"he": "התמרה",
"hr": "Supstitucija",
"hu": "Szubsztitúció",
"id": "Substitusi",
"it": "Sostituzione",
"ja": "置換",
"ko": "치환",
"lv": "Aizvietošana",
"nb": "Substitusjon",
"nl": "Substitutie",
"pl": "Substytucja",
"pt-BR": "Substituição",
"pt-PT": "Substituição",
"ro": "Substituție",
"ru": "Замещение",
"sk": "Substitúcia",
"sl": "Substitucija",
"sv": "Substitution",
"th": "การแทนที่",
"tr": "Yer değiştirme",
"uk": "Заміщення",
"vi": "Thế",
"zh-Hans": "取代",
"zh": "取代"
}Starting Material
C[O-]
Product
COC
Reagents
R-X (alkyl halide), alkoxide
Mechanism
[
{
"smiles": "C[O-]",
"description": {
"en": "Methoxide anion (from NaH + MeOH)",
"ar": "Methoxide أنيون (من NaH + MeOH)",
"cs": "Methoxide anion (z NaH + MeOH)",
"da": "Methoxide anion (fra NaH + MeOH)",
"de": "Methoxide anion (aus NaH + MeOH)",
"el": "Methoxide aniσε (από NaH + MeOH)",
"es-419": "Methoxide anión (desde NaH + MeOH)",
"es-ES": "Methoxide anión (desde NaH + MeOH)",
"es": "Methoxide anión (desde NaH + MeOH)",
"fi": "Methoxide anion (lähtien NaH + MeOH)",
"fr": "Methoxide anion (à partir de NaH + MeOH)",
"he": "Methoxide אניון (מ NaH + MeOH)",
"hr": "Methoxide anion (iz NaH + MeOH)",
"hu": "Methoxide anion (ebből NaH + MeOH)",
"id": "Anion metoksida (dari NaH + MeOH)",
"it": "Methoxide anione (da NaH + MeOH)",
"ja": "メトキシドアニオン（NaH + MeOHから）",
"ko": "메톡사이드 음이온(NaH + MeOH에서 생성)",
"lv": "Methoxide anions (nav NaH + MeOH)",
"nb": "Methoxide anion (fra NaH + MeOH)",
"nl": "Methoxide anion (uit NaH + MeOH)",
"pl": "Methoxide anion (z NaH + MeOH)",
"pt-BR": "Methoxide ânion (de NaH + MeOH)",
"pt-PT": "Methoxide ânion (de NaH + MeOH)",
"ro": "Methoxide anion (din NaH + MeOH)",
"ru": "Methoxide анион (из NaH + MeOH)",
"sk": "Methoxide anion (z NaH + MeOH)",
"sl": "Methoxide anion (iz NaH + MeOH)",
"sv": "Methoxide anion (från NaH + MeOH)",
"th": "แอนไอออนเมทอกไซด์ (จาก NaH + MeOH)",
"tr": "Methoxide aniüzerinde (den NaH + MeOH)",
"uk": "Methoxide аніон (з NaH + MeOH)",
"vi": "Anion methoxide (từ NaH + MeOH)",
"zh-Hans": "甲氧基阴离子（由 NaH + MeOH 得到）",
"zh": "甲氧基阴离子（由 NaH + MeOH 得到）"
}
},
{
"smiles": "CI",
"description": {
"en": "Methyl iodide (1° halide works best)",
"ar": "ميثيل يوديد (1° هاليد يعمل أفضل)",
"cs": "Methyl jodid (1° halogenid funguje nejlepsi)",
"da": "Methyl iodid (1° halid works best)",
"de": "Methyl Iodid (1° Halogenid works best)",
"el": "Methyl ιωδίδιο (1° αλογονίδιο λειτουργεί best)",
"es-419": "Metil yoduro (1° haluro works mejor)",
"es-ES": "Metil yoduro (1° haluro works mejor)",
"es": "Metil yoduro (1° haluro works mejor)",
"fi": "Methyl jodidi (1° halidi works best)",
"fr": "Méthyle iodure (1° halogénure works meilleur)",
"he": "מתיל יודיד (1° הליד עובד הטוב ביותר)",
"hr": "Metil jodid (1° halogenid djeluje najbolji)",
"hu": "Methyl jodid (1° halogenid működik best)",
"id": "Metil iodida (halida 1° bekerja paling baik)",
"it": "Metile ioduro (1° alogenuro works migliore)",
"ja": "ヨードメタン（1°ハライドが最適）",
"ko": "메틸 아이오다이드(1° 할라이드가 가장 잘 작동)",
"lv": "Metil jodids (1° halogenids darbojas labakais)",
"nb": "Methyl jodid (1° halid works best)",
"nl": "Methyl jodide (1° halide works best)",
"pl": "Metyl jodek (1° halogenek dziala najlepszy)",
"pt-BR": "Metil iodeto (1° haleto works melhor)",
"pt-PT": "Metil iodeto (1° haleto works melhor)",
"ro": "Metil iodură (1° halogenură works cel mai bun)",
"ru": "Метил иодид (1° галогенид работает лучший)",
"sk": "Metyl jodid (1° halogenid funguje najlepsi)",
"sl": "Metil jodid (1° halogenid deluje najboljsi)",
"sv": "Methyl jodid (1° halid works best)",
"th": "เมทิลไอโอไดด์ (เฮไลด์ 1° ใช้ดีที่สุด)",
"tr": "Methyl iyodür (1° halojenür çalışır best)",
"uk": "Метил йодид (1° галогенід працює найкращий)",
"vi": "Methyl iodide (halide 1° hiệu quả nhất)",
"zh-Hans": "碘甲烷（1° 卤代物效果最好）",
"zh": "碘甲烷（1° 卤代物效果最好）"
}
},
{
"smiles": "COC",
"description": {
"en": "Dimethyl ether via SN2",
"ar": "Dimethyl إيثر عبر SN2",
"cs": "Dimethyl ether pres SN2",
"da": "Dimethylether via SN2",
"de": "Dimethylether über SN2",
"el": "Dimethyl αιθέρας via SN2",
"es-419": "Dimetil éter vía SN2",
"es-E...Tips
[
{
"en": "Best method for making ethers",
"ar": "Best طريقة لـ making إيثرات",
"cs": "Nejlepsi method pro making ethery",
"da": "Bedste metode til fremstilling af ethere",
"de": "Beste Methode zur Herstellung von Ethern",
"el": "Best method για makσεg αιθέρες",
"es-419": "Mejor method para making éteres",
"es-ES": "Mejor method para making éteres",
"es": "Mejor method para making éteres",
"fi": "Paras menetelmä eetterien valmistukseen",
"fr": "Meilleur method pour making éthers",
"he": "Best שיטה עבור making אתרים",
"hr": "Najbolji method za making eteri",
"hu": "Best method számára makbang éterek",
"id": "Metode terbaik untuk membuat eter",
"it": "Migliore method per making eteri",
"ja": "エーテル合成の最良法",
"ko": "에터를 만드는 가장 좋은 방법",
"lv": "Labakais method prieks making eteri",
"nb": "Beste metode for å lage etere",
"nl": "Beste methode om ethers te maken",
"pl": "Najlepszy method dla making etery",
"pt-BR": "Melhor method para making éteres",
"pt-PT": "Melhor method para making éteres",
"ro": "Cel mai bun method pentru making eteri",
"ru": "Лучший method для making эфиры",
"sk": "Najlepsi method pre making etery",
"sl": "Najboljsi method za making etri",
"sv": "Bästa metoden för att framställa etrar",
"th": "วิธีที่ดีที่สุดในการสร้างอีเทอร์",
"tr": "Best method içiçinde makiçindeg eterler",
"uk": "Найкращий method для making етери",
"vi": "Phương pháp tốt nhất để tạo ete",
"zh-Hans": "制备醚的最佳方法",
"zh": "制备醚的最佳方法"
},
{
"en": "Use 1° or methyl halides (SN2 mechanism)",
"ar": "استخدم 1° أو ميثيل هاليدات (SN2 آلية)",
"cs": "Pouzijte 1° nebo methyl halogenidy (SN2 mechanismus)",
"da": "Use 1° eller methyl halides (SN2 mekanisme)",
"de": "Use 1° oder methyl halides (SN2 Mechanismus)",
"el": "Χρησιμοποιήστε 1° ή methyl αλογονίδια (SN2 μηχανισμός)",
"es-419": "Use 1° o metil haluros (SN2 mecanismo)",
"es-ES": "Use 1° o metil haluros (SN2 mecanismo)",
"es": "Use 1° o metil haluros (SN2 mecanismo)",
"fi": "Use 1° tai methyl halides (SN2 mekanismi)",
"fr": "Use 1° ou méthyle halogénures (SN2 mécanisme)",
"he": "השתמש 1° או מתיל הלידים (SN2 מנגנון)",
"hr": "Koristi 1° ili metil halogenidi (SN2 mehanizam)",
"hu": "Hmintználd 1° vagy methyl halogenidek (SN2 mechanizmus)",
"id": "Gunakan halida 1° atau metil (mekanisme SN2)",
"it": "Use 1° o metile alogenuri (SN2 meccanismo)",
"ja": "1°またはメチルハライドを使う（SN2機構）",
"ko": "1° 또는 메틸 할라이드를 사용(SN2 메커니즘)",
"lv": "Lieto 1° vai metil halogenidi (SN2 mehanisms)",
"nb": "Use 1° eller methyl halides (SN2 mekanisme)",
"nl": "Use 1° of methyl halides (SN2 mechanisme)",
"pl": "Uzyj 1° lub metyl halogenki (SN2 mechanizm)",
"pt-BR": "Use 1° ou metil haletos (SN2 mecanismo)",
"pt-PT": "Use 1° ou metil haletos (SN2 mecanismo)",
"ro": "Use 1° sau metil halogenuri (SN2 mecanism)",
"ru": "Используйте 1° или метил галогениды (SN2 механизм)",
"sk": "Pouzi 1° alebo metyl halogenidy (SN2 mechanizmus)",
"sl": "Uporabi 1° ali metil halogenidi (SN2 mehanizem)",
"sv": "Use 1° eller methyl halides (SN2 mekanism)",
"th": "ใช้เฮไลด์ 1° หรือเมทิลเฮไลด์ (กลไก SN2)",
"tr": "Kullanın 1° veya methyl halojenürler (SN2 mekanizma)",
"uk": "Використовуйте 1° або метил галогеніди (SN2 механізм)",
"vi": "Dùng halide 1° hoặc methyl (cơ chế SN2)",
"zh-Hans": "使用 1° 或甲基卤化物（SN2 机理）",
"zh": "使用 1° 或甲基卤化物（SN2 机理）"
},
{
"en": "Bulky alkoxide + 3° halide → elimination instead!",
"ar": "ضخم alkoxide + 3° هاليد → حذف بدلًا من ذلك!",
"cs": "Objemny alkoxide + 3° halogenid → eliminace misto!",
"da": "Store alkoxide + 3° halid → elimination instead!",
"de": "Sperrige alkoxide + 3° Halogenid → elimination instead!",
"el": "Bulky alkoxide + 3° αλογονίδιο → αποβολή σεstead!",
"es-419": "Voluminoso alkoxide + 3° haluro → eliminación instead!",...Related Reactions
sn2-bromide-hydroxide
Is Free
false